HOW CANNABIS AFFECTS EVERYONE DIFFERENTLY
photo credit - Happy and Sad - Choose the right medicine
HOW CANNABIS AFFECTS EVERYONE DIFFERENTLY
You've probably noticed by now, we're not all cookie cutter. Even within the same family, there can be incredible differences - and similarities in genetic expression. Think about the Bee Gees or the Jackson Family. There are all shapes and sizes in there. How many of your friends are mirror images - or are even vaguely similar to one another? In sports, fans ask the question, who is going to be the next Michael Jordan? The probable answer is no one. If you look at all the greats; Larry Bird, Wilt Chamberlain, Dr. J., Lebron, Magic and then do the analysis. Do you agree that while they all share the qualities it takes to be a winner, these superstars have little in common as far as their basic personality goes and even their body structures are anything but cookie cutter.
THE SCIENCE OF CANNABIS AND ITS INCREDIBLE DIVERSITY
In the plant kingdom, this expression of diversity in genetic expression cannot be better demonstrated than in the case of Marijuana. The "original" hemp plant was used for everything food, industrial oil, textiles material, paper, medicine, sacrament, building material, soaps, livestock feed and recreational use.
In the case of medical marijuana, the effects of a strain of Cannabis high in THC can cause one person to relax who goes off to write a great song, while another might lapse into a strange mindset where the they have the living bejesus scared out of them without reason.
Part of the varied response to weed has been found to be depend on the MMJ user's genetics, part of it involves the body's biochemistry of the moment, plus there are environmental factors that affect the response. Also, there are about 10 major cannabinoids that may be present in amounts that cause a psychological and medicinal effects. Plus there is more, cannabinoids are not the only medicinal compounds in the Cannabis plant.
There are also about a dozen terpenes present in marijuana that enhance and balance side effects - like temporary THC induced psychosis. In fact, non-psychoactive Cannabidiol CBD and terpenes have been found to reduce anxiety and paranoia brought on by an excessive intake of stoner pot, high in THC.
In Cannabis herbal medicine, 2 + 2 doesn’t equal 4. It equals 5 or more.
The “entourage effect,” results when hundreds of natural components within a plant interact together and with the human body to produce a stronger influence than any one of those components used alone. It’s a synergistic effect. When we combine multiple compounds in their natural state, we don’t end up with the sum of the parts; instead we get a multiplying effect. The different compounds can amplify each other’s effects, making the overall plant more effective in treating detrimental conditions and symptoms. - Paraphrase, CBD Oil Review.
The "Father" of Medical Cannabis, Dr. Rafael Mechoulam, an Israeli researcher who discovered THC, tested the pure compound - 10 mg. each - on his friends. The results were surprising.
Everyone responded differently. Some said nothing happened, but they were turned into a chatter box and never stopped talking. Another reported no effects also but kept bursting into hysterical laughter. One laid back on the couch and drifted off into their own little world, contemplating new aspects of the universe. Then, of course, there was a lady who became suddenly paranoid that her scandalous inner secrets were about to be exposed and there was no chance for defense. In conclusion, right off the get go, a primitive experiment revealed most of the classic psychological effects of high -THC weed.
The astute Dr. Mechoulam took little time to figure out that the varying psychological response was due to the cannabinoid THC and individuality. However, Dr. Mechoulam's basic findings were lost upon many future researchers that dealt with marijuana in a clinical setting. Early studies asked the question over simplistic question, is marijuana good or bad, does it cure such and such or not? A review of most of the peer reviewed papers from the period (1970-2000) reveals in incredible naivety; the type of Marijuana was not properly categorized and important components like cannabidiol and cannabinol were rarely mentioned and even THC was not always quantified (in the raw herb).
"I assume that the US will gradually make clinical research with cannabis and cannabinoids easier. This has already happened here and in some European countries. I understand that in the US the wind already blows in this direction."- Dr. Raphael Mechoulam
Thankfully, many of today's studies are of a reasonable - useful quality, some that perhaps might meet the approval of Dr. Mechoulam himself. From the literature, we provide the five main variables that affect an individual's response to Cannabis.
THE INCREDIBLE GENETIC DIVERSITY OF MARIJUANA
Each variety, strain or even individual marijuana plant coming from seed can have a unique cannabinoid profile, distinct taste and fragrance;' a property that is not found (to date) in any other plant . The manipulation in the quality of dozens of terpenes and cannabinoids implies that there are millions of possible variations that will feature their own unique flavours and medical effects. For example, a strain high in CBD and low in THC was said (by the mother of the patient) to literally cure a young woman's epilepsy. However another high CBD strain did not work so well. It turned out that the most effective CBD (in this case) strain also contained a terpene called myrcene.
The wide range of flavours and effects offered by the different strains of marijuana also helps you to avoid developing tolerance to its effects: when you have a single variety, the user and his or her body will develop a resistance – tolerance – to the properties of the plant consumed. The fun is only beginning with the other cannabinoids (CBD, CBN, CBC, CBG …) as non-THC forms of medicinal weed are becoming increasingly popular.
"Cannabis is one of humanity’s oldest crops, with records of use dating to 6000 years before present. Possibly because of its early origins, and due to restrictions on scientific inquiry brought about by drug policy, the evolutionary and domestication history of Cannabis remains poorly understood. Hillig (2005) proposed on the basis of allozyme variation that the genus consists of three species (C. sativa, C. indica, and C. ruderalis), whereas an alternative viewpoint is that Cannabis is monotypic and that observable subpopulations represent subspecies of C. sativa. The putative species C. ruderalis may represent feral populations of the other types or those adapted to northern regions." - Agriculture Canada
Endocannabinoids are naturally occurring chemicals made by the body that modulate receptors found in body and brain cells. In affect, feelings, emotion and sensations of hunger and pain are controlled by endocannabinoids. The active ingredients, called cannabinoids, act much like natural endocannabinoids. The response of Cannabis is highly dependent on the levels of the particular endocannabinoids in the system - at the time of consumption. It should be noted that some cannabinoids and terpenes have been found to "tone" down the action of other cannabinoids, so the relationship of cause and effect is not straightforward.
Most segments of your genetic code can be found in millions or billions of other humans, however, your particular combination of genes is unique. Furthermore, recently it has been found that the expression of your genes can depend - profoundly - on your lifestyle, environment and even personal disposition.
This means that an individual is far more adaptable than was previously thought. In the case of medical marijuana, cannabinoids and other medicinal ingredients inter-interact with several receptors and is involved in stimulating or slowing metabolic rate. As a result, the amount or way a particular receptor is modulated depends on - the genetic expression that affects the transport of CBD to the receptor site and the response of the receptor themselves.
The Cannabinoid - receptor process and drug interactions
"CNR1 cannabinoid receptor 1. This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene." - Gene ID: 1268, 6-Aug-2016
Recent research has shown that Cannabis use in individuals with a certain genetic mutation (or perhaps an expression) is associated with an abnormal response of anxiety, psychosis and paranoia. Other research has shown that a certain genetic expression causes Endocannabinoids to be produced in abundance which results in a super high appetite for love, food, sex and living. These people do not usually smoke pot much because their tanks are pretty much full already.
DEEP RESEARCH ON THE ENDOCANNABINOID SYSTEM
"The endocannabinoid system is powerful and nearly ubiquitous in the nervous system. The cannabinoid receptors dispersed throughout many brain regions are responsible for regulation of numerous aspects of neuronal activity, and account for the bewildering variety of behavioral and psychological effects caused by THC. Depending on the nervous system regions and maladies involved, either stimulating or inhibiting the endocannabinoid system could have beneficial effects. A great deal of attention is being given to incorporating non psychotropic cannabinoids into medicinal preparations, although in most cases the actual effects of these agents on the nervous system are unknown. For some purposes, drugs that are restricted to acting on peripheral cannabinoid receptors, and are prevented from entering the central nervous system, could be effective. Finally, therapeutic strategies aimed at developing regionally selective targeting of endocannabinoid system components, perhaps in combination with agents that affect conventional neurotransmitter systems, or non psychotropic cannabinoids, offer promise for future advances." - Getting High on the Endocannabinoid System
GENDER SPECIFIC EFFECTS
Cannabis generally affects men and women quite differently. Men are more likely to get hungry, while women tend to experience multiple-sensations. Marijuana tends to kill pain better in women than men, so big boys need a higher dose for equal effectiveness. It turns out that Estrogen and THC interact and work in synergy. - Estrogen increases cannabis sensitivity
"Psychology professor Rebecca Craft showed that, thanks to their estrogen levels, female rats are at least 30 percent more sensitive than males to the pain-relieving qualities of THC--the key active ingredient in cannabis.'
Since the levels of Estrogen (and Testosterone) vary wildly in a woman's monthly cycle, this estrogen-THC relationship should be studied by practicing Medical Marijuana Doctors, especially those that recommend Cannabis for "women's" issues like PMS, cramps, menstrual pain, and migraine.
Biochemistry affects the uptake, metabolism and action of the medical components of Cannabis. Some people can hold their beer, some cannot. Some can drink a gallon of coffee while others get the jitters with one strong cup. Why? It is a combination of things, mineral levels, diet, exercise, genetics, toxic agents, sleep and lifestyle all contribute to an individual's biochemistry.
For example, since human endocannabinoids are biosynthesized from omega (fish-oil) fatty acids, a person with a diet low in omega-3 oils will result in a deficiency of endocannabinoids. These people will tend to self medicate with marijuana not knowing anything else except that weed makes them feel good. This being the case, recreational use of Marijuana might be classified, often, as undirected medical therapy.
HEALTH - DISEASES - SYMPTOMS
People with health issues that use Cannabis are not going to respond in the same way as the average person. Conditions such as AIDS, Post Traumatic Stress Disorder or Fibromyalgia cause imbalances in biochemistry which affect the action of the cannabinoids in marijuana. In these cases, Cannabis is particularly effective in restoring or balancing the natural endocannabinoid system's chemistry that modulates;pain, appetite, digestion, mood, and inflammatory/immune response.
The effect of cannabinoids depends on your tolerance. As discussed previously tolerance depends on many things such as genetics, environmental issues, diet. Regular cannabis smokers build up a tolerance to THC. The more that is consumed, the greater the tolerance. However, the tolerance level tends to plateau and maxes out. This means that in treating chronic issues such as spine and neck pain, the dose is going to have to be increased over time. It is also wise to investigate complementary therapies, such as diet, acupuncture, exercise and other non-harming drugs and herbs.
Under that laws of California, Prop. 215 a legal doctor's recommendation entitles you to:
Marijuana possession and cultivation for personal medical use under Health and Safety Codes 11357 (HSC) and 11358
Hashish and concentrated cannabis, including edibles under HSC 11357a
Transportation of medical marijuana (HSC 11360) by a certified collective or personal caregiver
SB-20 provides protection against charges for possession for sales (11359), transportion, furnishing, providing or renting space for the distribution of a controlled substance (11366.5, 11570) and other issues (11360)
TERPENES - THE UNEXPLORED FRONTIER OF CANNABIS CLINICAL RESEARCH
ONLINE MMJ RECOMMENDATIONS - CANNABIS ID CARDS - GROWERS PERMITS
FAST, AFFORDABLE AND EASY PROCESS
Good medical cannabis professionals or astute practitioners of marijuana arts and sciences know that marijuana affects everyone differently. Now that lab testing is available, it has become much easier to establish cause and effect. While most lab tested marijuana is not fully quantitated for every cannabinoid and terpene present, values for the main components of CBD and THC are provided routinely. Equipped with this basic information, physicians and users alike can track the effect of different strains with varying CBD:THC ratios - and focus on what kind of cannabis medicine works best to treat their conditions and symptoms.
To buy medical-grade lab-tested marijuana in California, you must have a legal 420 Recommendation from a California licensed doctor. The California Board of Medicine Telehealth policies allows for the issue of Cannabis ID Cards, Cannabis Recommendations and Grower's permits over the internet.
Click here for an Online Doctor's Evaluation NOW - it only takes a few minutes and patients don't pay until they're approved.
Each marijuana plant coming from seed has a cannabinoid profile, unique taste and olfactory molecules, which are not found in the same way in any other plant. This combination of possibilities creates.
Researchers looked at the genotypes of 81 marijuana and 43 hemp samples. Using the DNA variants in the cannabis genome, they were able to search for relationships between different plants. They found that cannabis plants, the three main three species (C. sativa, C. indica and C. ruderalis), were often incorrectly labeled.
Popular lore assigns different characteristics to marijuana plants. For example, Indica-type plants are believed to produce relaxing and sedative effects as opposed to more stimulating Sativa-type plants. The researchers found only a moderate correlation between the ancestry of marijuana strains reported by breeders and the ancestry inferred from their DNA. For example, a sample of Jamaican Lambs Bread, which is classified as C. sativa, was almost identical at a genetic level to a C. indica strain from Afghanistan.
A team of Canadian researchers has sequenced the genome of Cannabis sativa, the plant that produces both industrial hemp and marijuana, and in the process revealed the genetic changes that led to the plant's drug-producing properties. A simple genetic switch is likely responsible for the production of THCA, or tetrahydrocannabinolic acid, the precursor of the active ingredient in marijuana.
"The transcriptome analysis showed that the THCA synthase gene, an essential enzyme in THCA production, is turned on in marijuana, but switched off in hemp. Detailed analysis of the two genomes suggests that domestication, cultivation, and breeding of marijuana strains has caused the loss of the enzyme (CBDA synthase), which would otherwise compete for the metabolites used as starting material in THCA production."
Crude marijuana extract competed with estradiol for binding to the estrogen receptor of rat uterine cytosol. Condensed marijuana smoke also competed with estradiol for its receptor. Pure delta 9-tetrahydrocannabinol, however, did not interact with the estrogen receptor. Ten delta 9-tetrahydrocannabinol metabolites also failed to compete with estradiol for its receptor.
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