RHEUMATOID ARTHRITIS - FINDING YOUR WAY - PART 1
Medical Marijuana - Finding Your Way
How can I find out what kind of cannabis based medicine is best? In this two part series, we report on the trial and error process of an arthritis patient who sought to find the best form of cannabis medicine to best treat her condition and symptoms.
A 55 year old woman (Connie) was diagnosed with rheumatoid arthritis. Symptoms included swollen joints and pain so severe that walking was difficult at times. She tried a number of prescription drugs, including anti-inflammatory steroids without much success. Side effects became a major concern. Connie read that several articles that indicated that medical marijuana might offer a non-toxic solution for her rheumatoid arthritis.
So, Connie consulted her family physician, who had no experience with medical marijuana, but he none the less cheerfully recommended marijuana and so the adventure began. As is the case with so many patients, Connie had to make her own way to find what was the right medicine.
How do I get a medical marijuana (MMJ) doctor's recommendation?
What type of medical marijuana product should I take?
What is the dose?
What do I do about side effects?
What type of MMJ can I take at work?
What types are best for sleep?
What if MMJ does not work, what then?
Diagnosis: Symptoms and lab-tests strongly suggest the condition of Rheumatoid arthritis; Positive for RF (rheumatoid factor), positive for anti-CCP.
Symptoms: Pain, fatigue, swelling of joints, hot joints, morning stiffness lasting several hours.
Symptoms get better as day goes along, get worse with long walks, and weight workouts (feet). Barometric pressure changes appear to worsen symptoms.
MMJDoctoronline Notes: Rheumatoid factor (RF) is a measure of an autoantibody that is misdirected against the patient's own tissues) and is used to diagnose inflammatory disorders and other conditions. In combination with signs and symptoms, the RF factor is the criteria used to establish a rheumatoid arthritis.
Other diseases correlated with increased RF levels include chronic infection, cirrhosis, or scarring of the liver, cryoglobulinemia (or abnormal proteins in the blood), dermatomyositis (an inflammatory muscle disease), inflammatory lung disease, mixed connective tissue disease, lupus and cancer, HIV/AIDS, hepatitis, influenza, viral and parasitic infections, chronic lung and liver diseases and leukaemia.
ACCP is a test used to detect antibodies associated with inflammatory disorders and rheumatoid arthritis, especially. Together RF, ACCP with matching symptoms are very powerful markers of Rheumatoid Arthritis.
PATIENT DIRECTED TITRATION OF CANNABIS OIL - CBD AND THC
Response to Oral Cannabis Oil
Dose: 22.4 mg d9THC + 12.8 mg CBD (1 ml product #1, #2)
Response: No relief of symptoms. Side effect: Very dizzy and room spins. Effect lasted for more than 6 hours.
Dose: 5.8 mg d9THC + 19.2 mg CBD (0.25 ml product #1, 1.5 ml product #2).
Response: No relief of symptoms. Body buzz feeling.
Dose: Total 64.8 mg CBD, with 4 mg THC (5 doses of product #2 =12.8 mg - every 2-3 hours, approx.total . Response: No noticeable effect. No noticeable side effects.
Notes: Cannabis Oil medication was taken between meals.
CANNABIS OIL PRODUCT SPECIFICATIONS
CBD Product #1 Aphria Rideau Gold cannabis oil, THC 0.8 mg/ml, CBD 12.8 mg/ml (actual)
Potential THC+THCA 0.8 mg/ml - Potential CBD+CBDA 13.4 mg/ ml
Equivalency factor 1 g. dry marijuana = 6 ml oil
Ingredients: medium chain triglycerides (MCT) oil, cannabis, trace d9THC, CBD, CBDA
THC Product #2 Aphria Champlain Indica cannabis oil, THC 22.5 mg/ml, CBD <0.5 mg/ml (actual)
Potential THC+THCA 21.5 mg/ml - Potential CBD+ CBDA<0.7 mg/ml
Equivalency factor 1 g. dry marijuana = 6 ml
Ingredients: medium chain triglycerides (MCT), cannabis, d9THC, d9THCA, trace CBD, & CBDA
Note: THC is psychoactive and reacts as a medicine differently than THCA, which is not psychoactive. THCA converts to THC upon heating in the manufacture process. CBD and CBDA are both nonpsychoactive.
After these three initial trials Connie learned three things. THC orally did not work alone or with CBD. CBD did not help symptoms at least initially. It remains to be seen if CBD works over the long haul.
In the next phase of trials, Connie will be trying different strains with THCV, THC and CBD, and cannabinol that have been successful in patients in her age group with the same symptoms. Cannabis meds in the second round of trials are taken via inhalation using a vaporizer and also creams.
Below, read how Connie sourced the information she needed to find the best prospective cannabis based medicines. See Part 2 for the rest of the story....
"Marijuana seems to fight inflammation of the joints by activating or modulating CB2 receptors, which are present at elevated quantities in the joint tissues of arthritis patients."
FACEBOOK - FIND A FRIEND WITH ARTHRITIS AND SHARE NOTES
"Grab a large cup and settle down in your favorite reading chair. The chances are you'll find come across someone in the same age bracket, with the same symptoms and condition. If you find someone with interesting things to say, why not reach out and send a message, ask a question or even become a friend. Just click on the blue text and you'll connect immediately via Facebook. "
Without further ado, we bring you a composite of several major conversations from the Facebook matrix... about Marijuana and Rheumatoid Arthritis.
THE BEST OF RHEUMATOID ARTHRITIS GROUPS
Here are the sites that were recommended to Connie. You too can make friends with your doppleganger, your double on Facebook with your symptoms and conditions.
Arthritis Foundation on Medical Marijuana
RA Chicks : Women with Rheumatoid Arthritis
Rheumatoid Arthritis Forum
These data show that CBD, through its combined immunosuppressive and anti-inflammatory actions, has a potent anti-arthritic effect on CIA.
I’m 53 years old and I’ve been struggling with arthritis for 5 years now. It’s been getting worse and worse over the years. I wake up in the mornings with unbearable pain in my hands and knees. I can’t enjoy the activities I once enjoyed, like knitting and gardening, because it just hurts too much!
In a phase II double-blind, randomized, placebo-controlled, 5-week study of 58 rheumatoid arthritis patients, researchers assessed the efficacy of Sativex administered at night up to a maximum of 6 sprays per evening (16.2 mg THC + 15 mg CBD) in 31 patients compared with placebo in 27 patients. The primary outcome measure was morning pain on movement. Secondary outcomes included measures of pain at rest, sleep quality, morning stiffness, the Short-Form McGill Pain Questionnaire (SF-MPQ) and the 28-joint disease activity score (DAS28). Baseline scores (an average of the last 4 days of a 14-day baseline period) were compared with the average of the last 14 days of treatment (Blake 2006).
Studies from chronic cannabis smokers have provided much of the evidence for immunomodulatory [modifying or regulating the immune system] effects of cannabis in humans…
Cannabinoids can modulate both the function and secretion of cytokines [regulatory proteins] from immune cells.
ARTHRITIS TYPES - THE ARTHRITIS FOUNDATION
MMJDoctorOnline Notes: We specialize in online medical marijuana ID and recommendations.
Our 100 % online process takes only a few minutes of your time and today you can be approved to buy marijuana legally in California and Nevada. Our documents are accepted by licensed clinics, cannabis clubs, 420 cooperatives, and dispensaries. We also supply growers permits and renewals. Our Telemedicine process conforms to the guidelines set by the Medical Board of California.
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